CHANGES OF GLOMERULAR CAPILLARY WALL IN AMINONUCLEOSIDE NEPHROSIS OF RATS
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چکیده
منابع مشابه
Changes in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis.
Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the sh...
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Experimental renal disease was produced in young rats by daily subcutaneous injections of 6-dimethylamino purine, 3-amino-d-ribose (aminonucleoside). The physiologic, biochemical, and light microscopic changes were similar to those observed in human nephrosis. Electron microscopy of the glomeruli from animals which received seven or more daily injections of aminonucleoside revealed characterist...
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Beef liver catalase (mol wt 240,000) was injected intravenously into normal rats and rats made nephrotic with aminonucleoside of puromycin. The localization of the tracer in the kidneys was then studied by ultrastructural cytochemistry, 3 min-12 hr after injection. Passage of catalase into the urinary space in normal rats was restricted by the basement membrane and by the epithelial slit pore. ...
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Physiological studies (1-4) have indicated that increased glomerular permeability is the major cause of proteinuria in human and experimental nephrosis, but the ultrastructural basis for such protein leakage is poorly understood. Previous morphological studies using ferritin (tool wt 500,000) (5, 6) have shown that the glomerular basement membrane becomes more permeable to this particle in expe...
متن کاملModulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis.
This study assessed glomerular endothelin (ET)-1, ET-3, and ET-receptor A and B mRNA levels in puromycin aminonucleoside (PAN)-induced nephrosis. During the nephrotic stage, 8 days after PAN injection, ET-1 and ETB receptor mRNA were elevated by 2.8 +/- 0.8-fold (P < 0.01) and 2.4 +/- 0.9-fold (P < 0.01), respectively, as compared with controls. These mRNA levels decreased to control levels by ...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 1989
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.2.203